Research

We are a partner in TRICALS, the largest research initiative to find a cure for ALS. Forty-eight of the best research centers in 16 countries collaborate with patient organizations and fundraising organizations to achieve one common goal: finding effective treatments for ALS.

Italsgen

We are among the founders of ITALSGEN, an Italian Genetics Consortium.

How clinical research is articulated

Clinical research is defined as any research conducted on humans (healthy or sick) whose goal is to increase medical knowledge of specific diseases with the aim of developing new treatments, medical devices or diagnostic methods to ensure better patient care.

There are mainly two types of clinical studies:

Observational studies: data involving patients are collected and analyzed without any intervention or modification by the researcher. These types of studies are aimed at improving knowledge of a disease and its evolution over time.
Experimental studies (or clinical trials): the investigator makes direct interventions, that is, modifies the research conditions by applying therapeutic or preventive strategies to two or more groups of subjects. These studies are designed to verify the effects of experimental drugs, medical devices or diagnostic/therapeutic procedures in order to provide a scientific demonstration of their efficacy and safety.

Clinical trials involving new drugs to be brought to market are generally classified into 4 phases, each of which is designed to answer a different experimental question.

We have been part of the Phase 1 Clinical Trial Unit - Chronic and Degenerative Neoplastic Pathology of the Adult- PNCDA of the AOU City of Health and Science of Turin since 2021

CRESLA Laboratories Experimental Research

BASIC RESEARCH is considered an experimental or theoretical activity having as its purpose the expansion of knowledge, the specific application or use of which is not expected.

TRANSLATIONAL RESEARCH aims to transform the results obtained from basic research into clinical applications in order to improve and implement methods of prevention, diagnosis and treatment of human diseases. Translational research is often associated with the Anglo-Saxon expression: "From bench to bedside" to refer to the process by which the results of research conducted in the laboratory are used to develop new methods of patient treatment.

Experimental research conducted in CRESLA laboratories can be summarized by: "From bedside to bench and to bedside again." In fact, our activity starts from the analysis of samples (urine, saliva, blood samples, skin biopsies...) voluntarily provided by patients. These samples are used to identify any differences from healthy subjects (controls) or that are created in the course of the disease. In this way, an attempt is made, on the one hand, to provide the physician with a diagnostic and/or prognostic biomarker (not available to date) and, on the other hand, to identify the biological mechanisms altered by the disease, a key step in the development of drug therapies.

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